DNA METHYLATION LEVEL AND TELOMERE LENGTH AS A BASIS
FOR THE BIOLOGICAL AGING CLOCK MODEL CONSTRUCTION
A.L. Runov,1,2,* M.S. Vonsky,1,2 V. M. Mikhelson 1
1 Institute of Cytology RAS and
2 D.I. Mendeleyev Institute of Metrology, St. Petersburg;
* e-mail: tsinakan@gmail.com
Aging is a process that depends on a variety of both external and internal factors. The biological age of a
person determines body deterioration and the risk of age-related diseases. Currently, as indicators of biological
age are considered different characteristics including average length of telomeres in cells and the level DNA
methylation. We propose to combine the two approaches to create a model to assess the biological age of the
person. Application of qPCR to determina the length of telomeres and MS-HRM for analysis of DNA methylation
will help us to determine the parameters of interest quickly when using a minimum set of equipment.
Key words:
aging, biological clock, DNA methylation, telomere
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