DYNAMICS OF THE CELL CYCLE IN HUMAN ENDOTHELIAL CELL
CULTURE INFECTED WITH INFLUENZA VIRUS
A.R. Prochukhanova,1 O.G. Lyublinskaya,2 A.A. Azarenok,1 A. V. Nazarova,1
V.V. Zenin,2 I.N. Zhilinskaya 1,*
1 Institute of Influenza, Ministry of Health of Russian Federation and
2 Institute of Cytology RAS, St. Petersburg;
* e-mail: irina@influenza.spb.ru
Cell cycle in a culture of endothelial cells EAhy 926 infected with influenza virus was investigated. Cytometric
analysis of culture, synchronized using contact inhibition, has shown that the exposure to the influenza
virus in cells EAhy 926 lengthened S-phase of the cell cycle. This result has been tested and proven on culture
EAhy 926 treated with nocodazole. Compared with lung carcinoma cells A549, in which influenza virus provokes
the arrest of G0/G1 phase of the cycle, elongation of S-phase of cycle at a similar infection of endothelial
culture EAhy 926 indicates that the influenza virus differently affects the dynamics of the cell cycle according
to the origin of the infected culture.
Key words:
culture of endothelial cells, the cell cycle, influenza virus
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