THE ROLE OF MITOCHONDRIAL DYNAMICS IN CELL DEATH
D.D. Orlova,1,* V.G. Tribulovich,1 A.V. Garabadzhiu,1 N.A. Barlev,1,2 S. Martin 1,3
1 St. Petersburg State Technological Institute (Technical University),
2 Institute of Cytology RAS, St. Petersburg, Russia, and
3 Trinity College Dublin, Ireland;
* e-mail: orlova.daria.d@gmail.com
Mitochondria are dynamic organelles whose homeostasis is defined by two opposite processes: fission (or
fragmentation), or fusion. Fission of mitochondria results in generation of smaller organelles and fusion is
when they produce tubular or net-like structures. Although a number of proteins are already known to control
the process of fission/fusion additional regulators controlling these processes are being found. The Bcl-2 family
members take part in the regulation of apoptosis and according to the current view are involved in the mitochondrial
net-like structure maintenance. In this review we will discuss mechanisms of mitochondrial fission/fusion
regulation and summarize the available information on the role of Bcl-2 family members in the regulation
of mitochondrial fission/fusion dynamics.
Key words:
apoptosis, Bcl-2 family, cell death, mitochondrial fission (fusion)
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