LYSOPHOSPHATIDIC ACID AND HUMAN ERYTHROCYTE AGGREGATION
Yu. A. Sheremet’ev,1 A. N. Popovicheva, G. Ya. Levin
Scientific Research Institute of Traumatology and Orthopedics,
Ministry of Health of Russian Federation, Nizhniy Novgorod;
1e-mail: ya.sher@rambler.ru
The effects of lysophosphatidic acid on the morphology and aggregation of human erythrocytes has been
studied. Morphology of erythrocytes and their aggregates were studied by light microscopy. It has been shown
that lysophosphatidic acid changes the shape of red blood cells: diskocyte become echinocytes. Aggregation of
red blood cells (rouleaux) was significantly reduced in autoplasma. At the same time there is a strong aggregation
of echinocytes. This was accompanied by the formation of microvesicles. Adding normal plasma to echinocytes
restores shape and aggregation of red blood cells consisting of «rouleaux». A possible mechanism of action
of lysophosphatidic acid on erythrocytes is discussed.
Key words: erythrocytes, aggregation, autoplasma, echinocytes, «rouleaux», microvesicles, lysophosphatidic acid
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