RECONSTRUCTION OF THE CONNECTIVE TISSUE AS A RESULT OF TRANSPLANTATION
OF FIBRINS DERMAL EQUIVALENT TO THE WOUNDS OF EXPERIMENTAL ANIMALS
N. Yudintseva,1 N. Pleskach,1 L. Smagina,1 M. Blinova,1
I. Samusenko,2 G. Pinaev 1
1 Institute of Cytology RAS and 2 A. M. Nikiforov All-Russian Center for Emergency
and Radiation Medicine Emercom of Russia, St. Petersburg;
e-mail: yudintceva@mail.ru
We analyzed the effectiveness of wound healing in rats after application of the dermal equivalent (DE) based
on fibrin with dermal fibroblasts. Histological studies of newly formed dermis biopsy samples selected during
its recovery in the model wound in laboratory animals have shown a positive effect of DE on wound healing.
It was found a significant increase in the area of collagen fibers, in the number of prekapillaries, capillaries
and postkapillaries in the granulation tissue after application of DE compared with the control group, suggesting
a more intense repair.
Key words: fibroblasts, fibrin, collagen
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