MICRONUCLEAR AND ANTITUMOR ACTIVITIES OF TWO NEWLY SYNTHESIZED PYRIMIDINE DERIVATIVES
A. K. Nersesyan,1, * R. E. Muradyan,2 F. G. Arsenynan 2
1 National Centre of Oncology and 2 Institute of Fine Organic Chemistry,
Yerevan, Armenia;
* e-mail: armen.nersesyan@meduniwien.ac.at;
armenn@freenet.am
Micronuclear and antitumor activities of two newly synthesized iodides of pyrazolo[1,5a]pyrimidines were
investigated using mice model. It has been shown that both compounds are slightly toxic and have no antitumor
activity in mice with Ehrlich's ascites carcinoma. Only one of them has weak micronuclear activity. Both compounds
increase substantially micronuclear as well as antitumor activities of cyclophosphamide.
Key words: isodides of pyrazolo[1,5a]pyrimidines, mice, micronuclei, Ehrlich ascitic
carcinoma, antitumor action, cyclophosphamide
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