CYTOKINE-MEDIATED APOPTOSIS OF GRANULOCYTES EOSINOPHILICUS IN THE CASE OF EXPRESSED
EOSINOPHILIA OF BLOOD
L. S. Litvinova,1 N. V. Ryazantseva, V. V. Novitskiy, E. S. Grigor’eva
SEI HPE Siberian State Medical University, Health Department of the Russian Federation, Tomsk;
1 e-mail: larisalitvinova@yandex.ru
The influence of recombinant forms of cytokines (IL-5, IL-3 and eotaxin) on programmed destruction of
eosinophils obtained from patients with diseases associated with high eosinophilia of blood (malignant diseases
of system of blood, opisthorchosis) was studied in vitro. It was shown that all examined categories of patients irrespective
of their nosology demonstrated a low level of spontaneous apoptosis of eosinophils. Cultivation of
eosinophils isolated from peripheral blood of the patients with invasion O. felineus in vitro with r-IL-5, r-IL-3
and r-eotaxin decreased the number of eosinophilic cells undergoing apoptosis in comparison with spontaneous
one. At the same time, incubation of eosinophils obtained from the patients with malignant diseases of system of
blood, associated with eosinophilic syndrome, with r-IL-5, r-IL-3 and r-eotaxin allowed to ascertain the absence
of sensitivity of eosinophilic cells to the antiapoptotic effect of these cytocines.
Key words: eosinophil, apoptosis, cytokines, opisthorchosis, hemoblastosis
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