THE BRAIN DOPAMINE SIGNALING SYSTEM IN TYPE 2 DIABETES MELLITUS AND METABOLIC SYNDROME
A.O. Shpakov,1 K.V. Derkach, I.B. Sukhov
I. M. Sechenov Institute of Evolutionary Physiology and Biochemistry RAS, St. Petersburg, 194223;
1 e-mail: oa0584@mail.ru
Recently it has been found that the dysfunction of the brain dopamine signaling system not only lead to the
development of neurodegenerative diseases but also play an important role in the etiology and pathogenesis of
metabolic disorders, including type 2 diabetes mellitus (DM2) and metabolic syndrome (MS). The basis of this
is the dopamine-induced central regulation of feeding behavior, peripheral insulin sensitivity, and glucose and
lipid metabolism. The abnormalities in this regulation lead to insulin resistance, impaired glucose tolerance,
dyslipidemia, endoplasmic reticulum stress, and eventually to the development of DM2 and MS. The pathological
changes in the brain dopamine system can occur in overt DM2 and MS, being one of the causes of their
complications in the nervous, cardiovascular and excretory systems. In the review, the literature and our own
results on the structural-functional organization of the brain dopamine system, on the molecular alterations in
this system in DM2 and MS, as well as on the approaches to correct these alterations and to restore metabolic
and hormonal status were analyzed and systematized. It has been concluded that the brain dopamine system is
one of the most important targets for the treatment and prevention of DM2, MS and their complications.
Key words:
dopamine, dopamine system, hypothalamus, type 2 diabetes mellitus, metabolic syndrome,
bromocriptine, leptin, insulin resistance
| Back
| Contents
| Main |
