INFLUENCE OF TITANIUM COATING ON THE BIOCOMPATIBILITY OF POLYPROPYLENE IMPLANTS
I.I. Babichenko,1,* A.A. Kazantsev,2 D.L. Titarov,1 K.A. Shemyatovsky,1 N.M. Ghevondian,3
D.S. Melchenko,2 A.I. Alekhin 2
1 Peoples' Friendship University of Russia, Moscow, 117198, 2 Central Clinical Hospital, RAS, Moscow, 117593, and
3 M.M. Shemyakin-Yu. . Ovchinnikov Institute of Bioorganic Chemistry, RAS, Moscow, 117997;
* e-mail: babichenko@list.ru
Comparative analysis of the proliferative activity of inflammatory cells and distribution of collagen types I and III was carried out around the net materials of polypropylene and
titanium coating polypropylene using immunohistochemical method and polarization microscopy. Experimental modeling of implanted mesh material were made in the soft tissues
of the lumbar region of rats. On the 7th postoperative day, quantitative analysis of proliferating cells delected using antibodies to the Ki-67 protein showed, a significant decrease
(ð < 0.001) in the number of proliferating cells around the network elements of the polypropylene (29.1 ± 5.7 %), when compared to similar figures of infiltrates in titanium
coating polypropylene (33.6 ± 3.1 %). Similar patterns were found on the 30th day of the experiment - 15.9 ± 4.3 and 26.9 ± 3.6 % - respectively (ð < 0.001). Different types
of collagen fibers in the granulomas around various types of implanted mesh material were detected on sections stained with Sirius red at polarizing light. On the 7th day after surgery,
the ratio of collagen fibers type I and III in granulomas around the mesh material made of polypropylene was 1.085 ± 0.022 and this ratio around materials of titanium coated
polypropylene was higher- 1.107 ± 0.013 (ð = 0.017). On the 30th postoperative day in the interface area ratio I/III collagen significantly increased and amounted to
1.174 ± 0.036 and 1.246 ± 0.102, respectively (ð = 0.045). Assessing the impact of the use of titanium as a coating on the polypropylene, it can be argued that it promotes
the formation of collagen I type and a more mature connective tissue around the mesh of the implants.
Key words:
mesh materials, polypropylene, titanium coating polypropylene, Ki-67, collagen I, III type
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