EXTRACELLULAR VESICLES: INTERCELLULAR INFORMATION FLOW AND MEDICAL APPLICATIONS
A.B. Pupyshev
Novosibirsk State Medical University, Novosibirsk, 630091;
e-mail: apupyshev@mail.ru
The major features of extracellular vesicles secreted by mammalian cells are considered. Cell activation
caused by formation of pathology stimulates the secretion acutely. The vesicles (exosomes, microvesicles) are
enriched with annexin V, tetraspanin, miRNA. Exosomes are enriched especially by integrins, heat shock proteins.
Microvesicles contain elevated amounts of tissue factors, phosphatidylserine, mRNA. The vesicles carry
information about the pathological process, and microvesicles contain more proteins characteristic of inflammation
and death than exosomes. They are important mediators of inflammation and infection in the body, have
different effects on the immune system and the processes of carcinogenesis and neurodegeneration. However,
antigenic profiles of extracellular vesicles differ not profoundly in various pathologies and so far they help diagnostics
limitedly. The vesicles carry signals of genetic reprogramming of the cells and epigenetic stimulation,
connected with both protein factors and mRNA and miRNA. Profiles of miRNA vesicles produced by the various
pathological sources are studied actively and are useful as indicators of source and stage of cancer. Some
ways of therapeutic use of the vesicles are also considered.
Key words:
extracellular vesicles, exosomes, microvesicles, intercellular information flow, intercellular
vesicle regulation, biomarkers, antigen profile, miRNA profile, diagnostics
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