INCREASE IN CELL RADIOSENSITIVITY AFTER INHIBITION OF CELL ABILITY TO RECOVER
FROM POTENTIALLY LETHAL RADIATION DAMAGE
E.S. Evstratova,* V.G. Petin
A.F. Cyb Scientific Research Centre of Radiology of the P.A. Hertsen Federal Medical Research Centre
of the Ministry of Health of the Russian Federation, Obninsk, 249036;
* e-mail: ekevs7240@mail.ru
The paper presents new experimental results demonstrating the recovery of irradiated cells on a nutrient
medium, which usually occurs at a delay of cell division. Using the previously proposed method, the contribution
of such a recovery in radiation sensitivity of diploid yeast cells of different strains after exposure to ionizing
and ultraviolet radiation has been estimated. It is shown that the actual increase in cell radiosensitivity significantly
exceeds the expected one in the case of inhibition of the recovery from potentially lethal damage. These
data indicate that inhibition of cell ability to recover from potentially lethal radiation damage by exposing the
irradiated cells in non-nutritive medium in many cases serve as an indicator of suppression of the overall ability
of cells to repair. Experimental data indicating that it is not a universal rule are presented.
Key words:
radiosensitivity, recovery, ionizing radiation, UV light, hyperthermia, chemical sensitizers,
potentially lethal damage, yeast cells
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