THE EFFECT OF PLANT EXTRACTS ON THE CYCLOPHOSPHAMIDE INDUCTION
OF MICRONUCLEUS IN RED BLOOD CELLS OF OUTBRED WHITE MICE
N.A. Durnova, M.N. Kurchatova 1
Department of General Biology, Pharmacognosy and Botany Saratov State Medical University named after V.I. Razumovsky, 410012;
1 e-mail: kurchatova.marya@yandex.ru
Antimutagenic properties flavonoids extracts of the three plants Gratiola officinalis L., Helichrysum arenarium
L., anthocyanin forms Zåà mays L. were investigated. Analysis was performed by counting the micronucleus
in peripheral blood erythrocytes outbred white mice; the mutagen was cyclophosphamide. Selected extracts
reduce the number of micronucleus. Gratiola officinalis L. extract reduces the mutagenic action of cyclophosphamide
at a dose of 200 mg/kg, Helichrysum arenarium L. extract — at doses of 100 and 200 mg/kg
(maximum protective effect was observed at a dose of 200 mg/kg), anthocyanin forms Zåà mays L. extract at
doses of 50, 100 and 200 mg/kg (a dose of 50 mg/kg — maximum antimutagenic effect).
Key words:
micronucleus analysis, cyclophosphamide, antimutagenic effect, extracts, medicinal plants
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