IN VIVO EVALUATION OF POLYCAPROLACTONE-HYDROXYAPATITE
SCAFFOLD BIOCOMPATIBILITY
A.N. Ivanov,1 M.N. Kozadaev, N.V. Bogomolova, O.V. Matveeva,
D.M. Puchinyan, I.A. Norkin, Yu.E. Sal’kovskii, G.P. Lyubun
Saratov Scientific Research Institute of Traumatology and Orthopaedics;
1 e-mail: ads707@ya.ru
Biocompatibility is one of the main and very important properties for scaffolds. The aim of the present study
was to investigate cells population dynamics in vivo in the process of original polycaprolactone-hydroxyapatite
scaffold colonization, as well as tissue reactions to the implantation to assess the biocompatibility of the
matrix. It has been found that tissue reactive changes in white rats subside completely up to the 21st day after
subcutaneous polycaprolactone-hydroxyapatite scaffold implantation. Matrix was actively colonized by connective
tissue cells in the period from the 7th to the 21st day of the experiment. However, intensive scaffold
vascularization started from the 14th day after implantation. These findings suggest a high degree of the polycaprolactone-
hydroxyapatite scaffold biocompatiblilitye.
Key words:
scaffold, polycaprolactone, hydroxyapatite, biocompatibility
| Back
| Contents
| Main |
|
