RADIATION PRECONDITIONING OF MOUSE RETINA RESULTS IN TOLERANCE
TO MNU-INDUCED DEGENERATION AND STIMULATES RETINAL RECOVERY
V.A. Tronov,1,2,* Yu.V. Vinogradova,2 V.A. Poplinskaya,3
E.I. Nekrasova,4 M.A. Ostrovsky 2,4
1 N.N. Semenov Institute of Chemical Physics RAS, Moscow, 2 Joint Institute for Nuclear Research, Dubna,
3 N.K. Koltzov Institute of Developmental Biology RAS
and 4 N.M. Emanuel Institute of Biochemical Physics RAS, Moscow;
* e-mail: vtronov@yandex.ru
Emerging body of data indicate protecting effect of low level of stress (preconditioning) on retina. Our previous
studies have revealed a non-linear dose-response relationship for cytotoxic effect of both ionizing radiation
and N-methyl-N-nitrosourea (MNU) on mouse retina. Moreover, non-cytotoxic dose of MNU increased tolerance
of retina to following challenge dose of MNU. This result displays protection of retina through mechanism
of recovery. In the present study we used the mouse model for MNU-induced retinal degeneration to
evaluate the adaptive response of the retina to proton irradiation and implication of glial Muller cells in this response.
In this paper, we have shown that the recovery of the retina after exposure to genotoxic agents is associated
with an increased efficiency of DNA damage repair and lowered death of retinal photoreceptors.
Key words:
retina, ionizing radiation, N-methyl-N-nitrosourea, DNA damage, reparation, hormesis
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