TANDEM REPEATS IN RODENTS GENOME AND THEIR MAPPING
D.I. Ostromyshenskii,1,* I.S. Kuznetsova,1 A.S. Komissarov,1
I.V. Kartavtseva,2 O.I. Podgornaya 1
1 Institute of Cytology RAS, St. Petersburg, and 2 Institute of Biology and Soil Sciences,
Far East Department of RAS, Vladivostok;
* e-mail: necroforus@gmail.com
Tandemly-repeated sequences represent a unique class of eukaryotic DNA. Their content in the genome of
higher eukaryotes mounts to tens of percents. However, the evolution of this class of sequences is poorly-studied.
In our paper, 62 families of Mus musculus tandem repeats are analyzed by bioinformatic methods, and 7 of
them are analyzed by fluorescence in situ hybridization. It is shown that the same tandem repeat sets co-occure
only in closely related species of mice. But even in such species we observe differences in localization on the
chromosomes and the number of individual tandem repeats. With increasing evolutionary distance only some of
the tandem repeat families remain common for different species. It is shown, that the use of a combination of
bioinformatics and molecular biology techniques is very perspective for further studies of the evolution of tandem
repeats.
Key words:
tandem repeats, satellite DNA, mouse, Mus
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