INDUCTION OF DECIDUAL DIFFERENTIATION OF ENDOMETRIAL MESENCHYMAL STEM CELLS
A.P. Domnina,1,* P.V. Novikova,2 I.I. Fridlyanskaya,1 M.A. Shilina,1 V.V. Zenin,1 N.N. Nikolsky 1
1 Institute of Cytology, RAS, St. Petersburg, 194064,
and 2 Faculty of Medicine, St. Petersburg State University, St. Petersburg, 199034;
* e-mail: aldomnina@mail.ru
In this study, we compared the ability of human mesenchymal stem cells derived from menstrual blood (eMSCs) and mesenchymal stem cells (MSCs) from other tissues to
differentiate into decidual cells in vitro. It was demonstrated that during differentiation secretion of decidualization markers (prolactin and insulin-like growth factor
binding protein-1) increases in eMSCs from adipose tissue (MSC-AD). Thus, the ability of eMSCs to differentiate into decidual cells is much higher than MSC-BM or MSC-AD.
It makes eMSCs promising for application in cellular therapy of infertility associated with decidualzation insufficiency.
Key words:
endometrial mesenchymal stem cells, decidual differentiation, mesenchymal stem cells of bone marrow, mesenchymal stem cells of adipose tissue
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