TUMOR SUPPRESSOR p63 REGULATES EXPRESSION OF UBIQUITIN LIGASE Pirh2
A.A. Daks,1 A. V. Petukhov,1,2 O. Yu. Shuvalov,1 E.A. Vasilieva,1 G. Melino,3 N.A. Barlev,1,* O.A. Fedorova 1
1 Institute of Cytology, RAS, St. Petersburg, 194064,
2 Institute of Hematology, V. A. Almazov Federal North-Western Medical Research Centre, St. Petersburg, 197341,
and 3 Leicester University, Leicester, Great Britain;
* e-mail: nick.a.barlev@gmail.com
Transcription factor p63 is a member of the p53 protein family. Due to the high degree of structural similarity p53, p63, and p73 are known to have overlapping functions relating to
cell cycle regulation, apoptosis and tumor transformation. Furthermore, p63 plays crucial role in epidermal tissue development and differentiation. Pirh2 (product of RCHY1
gene) is an E3 ubiquitin ligase modifying all three members of the p53 family resulting in their subsequent proteasomal degradation. Our results demonstrate that p63, similar to p53,
is able to regulate expression levels of Pirh2. Importantly, Pirh2 expression is activated only by transcriptionally active iso-form of p63 - TAp63, but not the N-terminally truncated
ΔNp63.
Key words:
p63, p53, proteasome degradation, E3 ubiquitin ligase
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