HETEROGENEITY AND POSSIBLE STRUCTURE OF MESENCHYMAL STROMAL CELL POPULATION
O.V. Payushina,1 E.I. Domaratskaya
N. K. Koltzov Institute of Developmental Biology RAS, Moscow;
1 e-mail: payushina@mail.ru
Mesenchymal stromal cells (MSC) represent a heterogeneous population of cells that differ in morphology,
phenotype, ability to grow and differentiate, and other properties. Differences between MSC are related in part
to the influence of their microenvironment. However, the heterogeneity of these cells also is due to their parent-
progeny relationship. Hierarchical organization of the MSC population that comprises different categories
of oligopotent and multipotent cells, is complicated and poorly understood. This review includes data on morphological,
phenotypic and functional heterogeneity of MSC and its possible connection with the population
structure.
Key words:
mesenchymal stromal cells, heterogeneity, parent-progeny relationship, population structure
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