DISTRIBUTION IN EARLY MOUSE EMBRYOS OF FOREIGN mtDNA TRANSMITTED ALONG THE PATERNAL LINEAGE
M.E. Kustova,1 O.V. Kidgotko,1 V.A. Sokolova,1 M.G. Bass,1
F.M. Zakharova,1,2 V.B. Vasilyev 1,2
1 Institute for Experimental Medicine, St. Petersburg and 2 St. Petersburg State University;
e-mail: vadim@biokemis.ru
Transmission of foreign mtDNA along the paternal lineage founded by male mice (F0), and distribution of
that mtDNA in their progeny at early stages of prenatal development were studied. Transmitochondrial males of
F0 obtained after injection of human mitochondria into mouse zygotes has been shown to transmit foreign
mtDNA to subsequent generations. Individual peculiarities among the males studied, concerning transmission
of foreign mtDNA to the progeny, are likely to exist. Besides, the distribution of human mtDNA among blastomeres
of transmitochondrial embryos under study differed from that observed in previous investogation of its
inheritance along the maternal lineage.
Key words:
transmitochondrial mice, mtDNA paternal inheritance, neonatal development
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