EXPRESSION OF mRNA TRANSCRIPTION FACTORS RORC2 AND FoxP3 IN LYMPHOCYTES
IN PATIENTS WITH PULMONARY TUBERCULOSIS
T.E. Kononova,1,* O.I. Urazova,1 V.V. Novitskiy,1,2 E.G. Churina,1 P.A. Zakharova 1
1 State Budget Educational Institution of High Professional Education «Siberian State Medical University» of Ministry of
Health Care of the Russian Federation, Tomsk, and 1 National Research Tomsk State University;
* e-mail: kononova.te@gmail.com
Homeostasis of subpopulations Th17- and Treg-lymphocytes plays an important role in a holistic and coordinated
process of eradication of pathogens and preventing the spread of infection in the body. Study of molecular
mechanisms controlling the balance of these cells in the formation of immune deviation in the pathogenesis
of infection are particularly relevant. The article presents the results of a study of mRNA expression of transcription
factors Th17- and Treg-lymphocytes — RORC2 and FoxP3, respectively, as well as the presence of
these cells in peripheral blood in infectious disease (based on an example of infection caused by Mycobacterium
tuberculosis). It was established that during the infiltrative (regardless of drug susceptibility testing) and
disseminated drug-susceptible pulmonary tuberculosis accompanied by Th17-polarized differentiation of
T-lymphocytes, as evidenced by the increased number of CD4+CD161+IL17A+ cells in the blood in association
with increased mRNA expression of the transcription factor RORC2 in lymphocytes. In disseminated drug-resistant
pulmonary tuberculosis T-lymphocyte differentiation is carried out mainly in the direction of immunosuppressive
Treg-cells, as evidenced by the increase in their number in the blood in association with elevated
levels of mRNA expression of the transcription factor FoxP3 in lymphocytes.
Key words:
transcription factors, RORC2, FoxP3, Th17-lymphocytes, Treg-lymphocytes, pulmonary tuberculosis
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