THE POSSIBILITIES AND PERSPECTIVES OF USING SCAFFOLD TECHNOLOGY
FOR BONE REGENERATION
A.N. Ivanov,1 I.A. Norkin, D.M. Puchinyan
1 Scientific-Research Institute of Traumatology and Orthopedics, Saratov;
1 e-mail: sarniito@yandex.ru
The article deals with the one of the topical problem of tissue engineering — the design and implementation
of biomaterials that could replace and repair bone defects. This review presents the recent studies of the potential
of scaffold technology in bone tissue regeneration. This article contains information about the basic parameters
and properties of modern scaffold systems. The results of experimental in vitro and in vivo studies on
the use of matrices made of various materials are shown. Advantages and disadvantages of various materials
used for the production of scaffolds are discussed. Attention is paid to the advantages combinations of different
materials to achieve the desired structural and functional properties. Particular attention is paid to technologies
and systems of targeted delivery and controlled release of factors that stimulate bone tissue regeneration. Different
strategies for modulating tissue reactions and immune responses that take place during scaffold implantation
are presented.
Key words: scaffold, bone regeneration, growth factors
| Back
| Contents
| Main |
