ABERRANT EXPRESSION OF sox2 GENE IN MALIGNANT GLIOMAS
A.V. Volnitskiy,1 E.V. Semenova,1 T.A. Shtam,1 R.A. Kovalev,1 M.V. Filatov 1,2,*
1 B.P. Konstantinov’s Petersburg Nuclear Physics Institute, Gatchina,
and 2 St. Petersburg State Polytechnic University;
* e-mail: fil_53@mail.ru, filatov@omrb.pnpi.spb.ru
Both genetic and epigenetic changes underlite the mechanisms of tumor initiation and progression. In the
present study we analyze sox2 gene expression and its epigenetic regulation in primary cultures of malignant
gliomas. The sox2 expression was detected in the vast majority (74 %) of the investigated gliomas and absent in
morphologically normal brain tissue. This indicates the process of glioma malignant transformation. We have
also shown that the association of different areas of the sox2 gene with important epigenetic markers, posttranslational
modifications of H3 histone H3K4ac and H3K9met3, does not correlate with the sox2 expression. However,
this may indicate the stochastic nature of the regulation of sox2 gene expression in malignant gliomas.
Key words: aberrant gene expression, gliomas, posttranslational H3 histone modifications, Sox2
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