ROLE OF MICROPARTICLES IN INTERCELLULAR COMMUNICATION
D.A. Korenkov,1 O.M. Ovchinnikova, S.A. Selkov, D.I. Sokolov
D.O. Ott Research Institute of Obstetrics and Gynecology RAMS, St. Petersburg;
1 e-mail: d.korenkov@gmail.com
Adaptive reactions involving different body systems are essential for human living activity. These adaptive
reactions are based both on contact cell interactions and distant cell-to-cell transfer of secreted molecules. Transfer
of bioactive substances is realized both on system and local levels. Currently, there is lack of information
about mechanisms of transport in the intercellular space. Secretion of biologically active molecules within microparticles
is considered to be one of the possible modes of signal transduction. Microparticles are microvesicles
generated on the cell membrane surface. They may contain molecules derived from membrane, cytoplasm
and nucleus. Blood plasma microparticles are established to be involved in blood coagulation, inflammation
and immune response. In this review we summarize current concepts of microparticles as signal carriers participating
in intercellular communication.
Key words: intercellular communication, extracellular vesicles, microparticles
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