THE INFLUENCE OF TESTOSTERONE AND b-ESTRADIOL ÎN T-LYMPHOCYTES
ACTIVATION ASSOCIATED WITH IL-2 PRODUCTION AND EXPRESSION OF CD25
(IL-2Rα) MOLECULES
A.A. Gutsol, N.A. Sokhonevich, K.A. Kofanova, L.S. Litvinova 1
Baltic Federal University of Immanuel Kant, Kaliningrad;
1 e-mail: larisalitvinova@yandåõ.ru
We have shown that testosterone and β-estradiol in vitro have effects on naïve (CD45RA+) and priming
(CD45RÎ+) T-lymphocytes, which associated with the production of IL-2 and CD25/IL-2Rα expression. Testosterone
can inhibit naïve and priming T-cell function activity in our study. Moreover it was shown that naïve
lymphocytes are more sensitive to testosterone than primed. We have found dose dependent suppressive β-estradiol
effect on IL-2 production by activated CD45RA+ and CD45RO+ lymphocytes which leads to uniform
decreasing CD25-positive T-cells number.
Key words: testosterone, β-estradiol, naïve T-cells, primed memory T-lymphocytes, cells activation
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