3-HYDROXY-1,5-DIARYL-4-PIVALOYL-2,5-DIHYDRO-2-PYRROLONES INDUCE THE MITOTIC EXIT FAILURE AND CELL DEATH IN TUMOR
CELLS IN VITRO
S.S. Zykova,1 S.V. Boichuk,2,* A.R. Galembikova,2 B.R. Ramazanov,2
I.G. Mustafin,3 N.M. Igidov,3 T.F. Odegova 3
1Perm Institute of the Federal Penal Service, 2 Kazan State Medical University
and 3 Perm State Pharmaceutical Academy;
* e-mail: boichuksergei@mail.ru
Some compound refering to the 3-hydroxy-1,5-diaryl-4-pivaloyl-2,5-dihydro-2-pyrrolones have been found to cause an increase in the number of mitotic cells and their
subsequent death in vitro. This increased in the number of mitotic cells was not associated with increased cellular proliferative activity and was likely due to mitotic exit
failure. Of note, the effect was more pronounced in the tumor cells when compared to human fibroblasts. Further studies are needed to investigate the molecular mechanisms
of action of the compounds belonging to the class of 3-hydroxy-1,5-diaryl-4-pivaloyl-2,5-dihydro-2-pyrrolones.
Key words: arylidenarylamines, acylpyruvic acid, 3-hydroxy-1,5-diaryl-4-pivaloyl-2,5-dihydro-2-pyr-rolones,
fibroblasts, tumor cells, mitotic catastrophe, apoptosis, anti-tumor activity
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