STRUCTURE OF AMYLOID-BETA PEPTIDES IN A COMPLEX WITH MODEL MEMBRANES
K.S. Usachev,1 A.V. Filippov, V.V. Klochkov
Kazan (Volga Region) Federal University, Laboratory for NMR Spectroscopy of Biological Systems;
1 e-mail: k.usachev@kpfu.ru
Structures of amyloid-beta peptides Aβ1-40, , Aβ10-35, Aβ13-23 and Aβ16-22 in a complex
with model mem-branes in solution were obtained on the analysis of NMR experimental data. It has been established that the process of peptide-micelle complex formation
occurs through the amino acid residues L17, F19, F20 and G29-M35.
Key words: Alzheimer disease, beta-amyloid, NMR, SDS micelle
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