EFFECT OF IODINE-CONTAINING THYROID HORMONES ON THE HISTOSTRUCTURE OF RAT LIVER UNDER THE STRESS
I.V. Gorodetskaya, E.A. Gusakova
Vitebsk State Medical University, Belorussia;
e-mail: gorodecka-iv@mail.ru
Experiments with 130 outbred male rats weighing 220.250 g have show that stress áfree swimming in a
cageâ (FSC) affects the histological structure of the liver as early as in 1 h. FSC occurred in standard plastic cages
(5 animals) filled with water to a height of 15 cm and topped with a grid. One hour after FSC (the alarm-stage)
caused dystrophy of hepatocytes and increased blood flow to the liver lobules, which also continued at the
resistance-stage (48 h after the FSC). At the exhaustion-stage (daily 1-hour stress for 10 days) there were even
greater hepatocytes dystrophy, necrosis, and their microcirculatory disturbances in the lobules. The introduction
of merkazolil (intragastrically 25 mg/kg for 20 days) per se altered the histostructure of the liver tissue and
under stress aggravates the microcirculatory changes, dystrophy and necrosis of the hepatocytes. Small doses of
L-thyroxine (intragastrically 1.5.3.0 ƒÊg/kg for 28 days) minimized the histological signes of the liver damage
at all stages of the stress response. Consequently, the iodine-containing thyroid hormones limit the disturbance
of the microstructure of the liver caused by stress.
Key words: liver, rat, stress, iodine-containing thyroid hormones
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