THE MANIFESTATION OF SYNERGY DURING SIMULTANEOUS THERMOCHEMICAL
ACTION ON YEAST CELLS
A.O. Omelchenko,1 E.S. Evstratova, L.N. Komarova, E.N. Ryzhykova
Medical Radiological Research Center of the Ministry of Health of the Russian Federation, Obninsk;
1 e-mail: a.o.omelchenko@mail.ru
In order to obtain new fundamental knowledge, patterns of manifestation of synergy have been studied after
simultaneous combined action of hyperthermia (47.5—60 °C) with anti-tumor agents (cyclophosphamide,
cisplatin) on the survival of yeast cells. To calculate the efficiency of the synergistic interaction, the dependence
of cell survival on the duration of exposure at separate and simultaneous action of chemical agents and hyperthermia
was used. We have found that there is a certain temperature range within which there is a synergistic
enhancement of anticancer drugs and high temperature effects. Any deviation from the optimum values of the
temperature results in a decrease in synergy. The possible mechanism of the revealed patterns is discussed.
Key words: synergy, hyperthermia, anti-tumor agents, yeast cells
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