RECELLULARIZATION OF TISSUE ENGINEERED VASCULAR GRAFTS
IN PERFUSION BIOREACTOR
A.S. Nasredinov,1,* S.V. Anisimov,1 V.N. Vavilov,1,2 M.V. Puzanov,1 D.I. Kurapeev 1
1 Federal V. A. Almazov Medical Research Centre, S.-Petersburg,
and 2 St. Petersburg First I. P. Pavlov State Medical University;
* e-mail: vsurg@yandex.ru
Small diameter tissue engineered vascular grafts could be a potential solution to the shortage of vascular
substitutes in reconstructive cardiovascular surgery. Previously, we have developed a decellularization method
for human umbilical arteries, which could be used as a scaffold in vascular tissue engineering. Objective of the
study was to optimize the recellelularization of decellularized scaffolds with mesenchymal stem cells. In the
study, the possibility of cell growth on decellularized vessel has been shown. We also has proved that the use of
perfusion-bioreactor improves the results of recellularization.
Key words: recellularization, umbilical artery, bioreactor
| Back
| Contents
| Main |
|
