THE INTERACTION BETWEEN SGLT1 OR GLUT2 GLUCOSE TRANSPORTER
AND THE CYTOSKELETON IN THE ENTEROCYTE AS WELL AS Caco2 CELL
DURING HEXOSE ABSORPTION
N.M. Grefner,1,* L.V. Gromova,2 A.A. Gruzdkov,2 Ya.Yu. Komissarchik 1
1 Institute of Cytology RAS and 2 I.P. Pavlov Institute of Physiology RAS, St. Petersburg;
* e-mail: ngrefner@yandex.ru
The distribution of cytoskeleton elements (microtubules and actin filaments) and SGLT1 or GLUT2 glucose
transporter in enterocyte of rat intestine and Caco2 cell during hexose absorption has been considered. The
alteration of SGLT1 and GLUT2 transporter distribution in absorptive cell of intestine villus depending on maltose
concentration has been determined using the confocal microscope. The colocalization of the transporters
and actin has been revealed. The increase of vesicles number close to microtubules in the apical part of cell
during absorption of high hexoze concentration has been found by electron microscope. The fact together with the
transporter and actin as well as actin and a-tubulin colocalizations can prove the participation of cytoskeleton
elements in glucose transporter movement to apical membrane of the cells studied.
Key words: enterocyte, Caco2 cell, cytoskeleton, microtubule, actin, SGLT1 and GLUT2 transporter,
glucose absorption
| Back
| Contents
| Main |
