RAT HEAT STRUCTURAL AND FUNCTIONAL CHARACTERISTICS AND GAS EXCHANGE
PARAMETERS AFTER EXPERIMENTAL MYOCARDIAL INFARCTION
E.V. Baidyuk,1,* G.A. Sakuta,1 L.P. Kislyakova,2 Yu.Ya. Kislyakov,2
S.V. Okovityy,3 B.N. Kudryavtsev 1
1 Institute of Cytology RAS, 2 Institute of Aerospace Instrumentation RAS and
3 Chemical Pharmaceutical Academy, St. Petersburg;
* e-mail: katya_bay@mail.ru
Rat heart structural and functional changes and gas exchange parameters were investigated in six months
after experimental myocardial infarction. Left ventricular end-systolic and end-diastolic dimensions in rats with
chronic heart failure were 78 and 30 % higher than in control respectively. Left ventricle cavity volume in systole
and diastole were 5 and 2 times increased respectively. Left ventricular cavity stretching was accompanied
by thinning of the interventricular septum. Left ventricular structural changes leads to its functional deterioration.
Left ventricular contraction fraction was reduced by 60 %, and the ejection fraction — by 52 % in comparison
with control. Gas exchange investigation revealed that in six month after myocardial infarction oxygen consumption
of operated rats was increased by 30 % and production of carbon dioxide by more than 40 %. Respiratory
quotient, which reflects the nature of oxidized substrates, in rats with myocardial infarction was amounted
to 0.85, indicating significant increase in the contribution of carbohydrates as an energy substrate for myocardial
metabolism.
Key words: myocardial infarction, chronic heart failure, respiratory quotient, echocardiography
| Back
| Contents
| Main |
|
