INFLUENCE OF IMMUNOREGULATORY CYTOKINES (IL-2, IL-7 AND IL-15) IN VITRO UPON ACTIVATION, PROLIFERATION AND APOPTOSIS
OF IMMUNE MEMORY T-CELLS
L. S. Litvinova,1 N. A. Sokhonevich, A. A. Gutsol, K. A. Kofanova
Laboratory for Immunology and Cell BiotechnologiesBaltic Federal Institute of Immanuel Kant, Kaliningrad, Russia;
1 e-mail: larisalitvinova@yandåõ.ru
Under the experimental conditions in vitro the effects of immunoregulatory cytokines (IL-2, IL-7 and IL-15) on the activation, proliferation and apoptosis of different
subpopulations of immune memory T-cell (CD45RO+) were investigated in healthy donors. It was demonstrated that the effects of rIL-2 in vitro equally affect
the activation and proliferation of CD4+ and CD8+ subpopulations of memory T cells. It is shown that high concentrations of rIL-2 lead to an increase in
the number of CD8+ memory cells expressing apoptotic molecule CD95. Different effect of rIL-7 and rIL-15 on the activation and proliferation of cytotoxic
CD8+ memory cells was revealed in vitro. CD4+ memory lymphocytes have relative resistance to the activation and proliferative effect of rIL-7
and rIL-15, if compared with the effects of rIL-2, that can provide their relative resistance to the activation apoptosis as well as create the necessary conditions for the accelerated
implementation of their functional capacity in the development of a secondary immune response.
Key words: memory T cells, cytokines, activation, proliferation, apoptosis
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