REACTION OF POPULATION OF PULMONARY MAST CELLS IN RAT BRONCHIAL ASTHMA UNDER THE EFFECT OF β-ADRENORECEPTOR ANTAGONISTS
I.L. Erokhina,1 P.A. Voronchikhin,2 S.V. Okovityy,2 O.I. Emelyanova 1
1 Institute of Cytology RAS, St. Petersburg and 2 Chemical Pharmaceutical Academy, St. Petersburg;
1 e-mail: heartdev@mail.cytspb.rssi.ru
Multifunctional granular mast cells (MCs) are among targets in bronchial asthma (BA) therapy. We studied pulmonary MC population in a rat model of BA under the effect of
β-adrenoreceptor antagonists and of the latter combined with the standard therapy (glucocorticoid budesonide + β2-adrenergic agonist salbutamol). MCs of different degrees
of maturity were identified on paraffin section of lung stained with Alcian blue and Safranin. MC density in the lung of rats with BA increased 1.9 times. Alcian blue-positive immature cells
predominated in the lungs of both intact rats and rats with BA. In response to pharmacological agents, the mean MC densities were reduced in 2-2.7 times in all the variants of experiments
and were close to the norm. It allows us to suppose that MCs migration from the outside was suppressed and, in consequence of the decline of MC densities, the release of the mediators
involved in the progression of BA may be diminished.
Key words: mast cells, lungs, bronchial asthma, rats, β-adrenoreceptor agonists, therapy
| Back
| Contents
| Main |
