MIGRATION RATE OF RABBIT BONE MARROW STROMAL CELLS AND RABBIT DERMAL FIBROBLASTS IN DIFFERENT GELS
AND ACTIVITY OF THEIR MMPS
N.Ì. Yudintceva, N.S. Nikolaenko, I.V. Voronkina, L.V. Smagina, G.P. Pinaev
Institute of Cytology RAS, St. Petersburg;
e-mail: yudintceva@mail.ru
The study of rabbit bone marrow stromal cells (BMSC) and rabbit dermal fibroblasts (DF) migration rate into collagen type I and fibrin gels was carried out in given paper.
It was shown that DF had more migration activity in collagen gel and BMSC in fibrin gels. By studying the activity of matrix metalloproteinases (MMPs) synthesized by cells during
cultivation into gels it was found that for both cell types the activity of MMP-9 was increased into fibrin gels and activity of MMP-2 was increased into collagen gels. Different speed
of the migration of cells can be caused by the properties of the cells, by the activity synthesized by them MMP and by influence on this process of the micro-environment of cells
(collagen or fibrin).
Key words: collagen type I, fibrin, dermal fibroblasts (DFs), matrix metalloproteinases (MMPs), bone marrow stromal cells (BMSCs)
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