EFFECT OF ZAJDELA ASCITE HEPATOMA GROWTH ON THE EXTRACELLULAR ANTIOXIDANT SYSTEM OF TUMOR BEARER
Potselueva M.M.,1,2 Naumov A.A.,1,2 Sukhomlin T.K.,1 Zinatullina G.G.,1,2 Shatalin Yu.V. 1,2
1 Institute of Theoretical and Experimental Biophysics, Russian Academy of Sciences, and 2 Pushchino State Institute of Natural Sciences;
e-mail: mpotselueva@rambler.ru
The influence of tumor development on the blood plasma antioxidant system in the area of tumor growth was studied. A Zajdela ascite hepatoma transplanted to the abdominal
cavity of Vistar rats was used as a model of tumor growth. It was found that tumor development produced an imbalance (unbalance) between pro- and antioxidant systems in the
organism of tumor bearer. Besides, a sharp decrease in tocopherol and uric acid concentrations (two times), as well as in the concentration of protein SH-groups (seven times)
was noted. In the tumor growth area, along with the tocopherol level decrease, a 5-7 fold increase in the concentrations of uric acid and protein SH-groups was observed. As the
concentration of low-molecular antioxidants decreases, the major part is played by protein components which bind or oxidizethe ions of variable valency. Thus, the level of transferrin
(Tf) which is responsible for the transport of iron ions in the blood plasma decreased 2.5 to 3 times (from 5.0 to 1.6 mg/ml) whereas in the ascitic fluid the Tf level increased from
1.5 to 2.7 mg/ml. The concentration dynamics of the other protein functioning together with Tf - ceruloplasmin (Cp) had opposite (inverse) tendencies. Thus, the Cp concentration in the
blood plasma grew 1.5-2 times (from 0.55 to 1.1 mg/ml) whereas in the ascites it decreased from 0.55 mg/ml to 0.35 mg/ml..
Key words: low molecular antioxidants, proteins of antioxidant system, oxidative stress, Zajdela hepatoma, tumor growth
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