LAMIN A/C MUTATIONS CHANGE DIFFERENTIATION POTENTIAL OF MESENCHYMAL STEM CELLS
A.B. Malashicheva 1,2, A.S. Zabirnik 3,4, N.A. Smolina 1, R.I. Dmitrieva 1, A.A. Kostareva 1
1 Almazov Federal Heart, Blood and Endocrinology Centre, Saint-Petersburg, Russia;
2 St. Petersburg State University, Saint-Petersburg, Russia;
3 V.N. Karazin Kharkiv National University, Kharkiv, Ukraine; 4 Cell biotecnology laboratory "Virola", Kharkiv, Ukraine;
e-mail: akostareva@hotmail.com
Mutations in lamin A/C gene (LMNA) lead to development of severe disorders - laminopathies. Unlike most other types of intermediate filaments, where the pathological effect
of mutations is tightly linked to alteration of mechanical and integrative function, the detailed mechanism of lamin mutations is still unclear and possibly involves the alteration of nuclear
signaling and transcriptional process. Since the mesenchymal lineage tissues such as myocardium, skeletal muscle, adipose and bone tissues are mostly affected in laminopathies, the role
of lamin A/C in differentiation process of mesenchymal stem cells was assumed. The aim of the study was to estimate the effect of LMNA mutations on differentiation of mesenchymal
stem cells into adipose lineages. In vitroKey words: lamin A/C, laminopathies, stromal cells of adipose tissue, differentiation, adipogenesis
| Back
| Contents
| Main |
|
