PROGRESS IN MAPPING THE YELLOW FEVER MOSQUITO GENOME
M.V. Sharakhova, I.V. Sharakhov
Department of Entomology, Virginia Polytechnic Institute and State University, Blacksburg, Virginia, United States of America;
e-mail: msharakh@vt.edu
Mosquito-borne diseases cause significant problems for the human health. For this reason, the genomes of three most dangerous species of mosquitoes, including the yellow
fever mosquito Aedes aegypti, were sequenced in last decade. The efficient vector of arboviruses Ae. aegypti, is also a convenient model for laboratory research.
The intensive genetic mapping of morphological and molecular markers conducted for this mosquito in the past was very successful. This mapping was also used as a tool to localize
a number of quantitative trait loci related to the mosquito's ability to transmit various pathogens. However, physical mapping of the Ae. aegypti genome is difficult due to the lack of
high-quality polytene chromosomes. Here, we review different mapping approaches that help improving genome sequence assembly for and also integrate linkage, chromosome and
genome maps the yellow fever mosquito.
Key words: mosquito Aedes aegypti, yellow fever, genome map
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