PROTEASOMES AND THEIR ROLE IN THE EXTRACELLULAR SPACE
Yu.Ya. Zaykova, I.N. Evteeva, A.S. Tsimokha
Institute of Cytology RAS, St. Petersburg;
e-mail: atsimokha@mail.cytspb.rssi.ru, vat-julia@yandex.ru
The presented review concerns the intracellular proteasome and their possible functions. The ubiquitin-proteasome system (UPS) is responsible for the common regulated
proteolysis in the cell. 26S proteasome is a central proteolytic unit of UPS and is a multisubunit protein complex consisting of a core catalytic complex, called 20S proteasome,
capped at one or both ends by 19S regulatory complex. Proteasomes have been shown in the extracellular space: in alveolar and cerebrospinal fluids, blood plasma. Extracellular
proteasomes are intact intracellular particles that exhibit three types of specific peptidase activity. Extracellular proteasomes have been detected in both healthy people and patients
with different diseases. Its concentration has been found to be increased in patients suffering from autoimmune diseases, malignant tumors, trauma or sepsis and to correlate with
the disease progression, which has both diagnostic and prognostic value.
Key words: circulating proteasomes, exosomes, extracellular proteasome, proteasomes, proteolysis, ubiquitin-proteasome system
| Back
| Contents
| Main |
