VIOLATION OF THE HOMOLOGOUS CHROMOSOMES RAPPROCHEMENT
AS THE ANSWER TO THE SMALL DOSES OF ROENTGEN IRRADIATION
A. Bernadotte,1,* V. M. Mikhelson,2 I. M. Spivak 2
1 Karolinska Institute, Stockholm, Sweden, and 2 Institute of Cytology RAS, St. Petersburg;
* e-mail: alexandra.bernadotte@ki.se
Any violation of the homologous chromosome DNA repair leads to the genome instability, characteristic
for hereditary syndromes and for aging cells. Using low doses of ionizing radiation (3—10 cGy) we have found
any transference of the homologous centromere loci of the chromosome 1 (1q12) from the periphery to the centre
of the nucleus in the lymphocytes of young healthy donors. The same effect was found after any influence of
RNA-polymerase inhibitor á-amanitine. Some changes in the chromatin structure during aging (70—80 years
old patients) result in the difficulties in chromosome displacement, accompanied with any trouble in the rapprochement
of the homologous chromosome loci as an answer to low doses of radiation.
