THE CELLS OF SYSTEM MONONUCLEAR PHAGOCYTES OF LIVER AND LUNG RATS AFTER INTRAVENOUS APPLICATION OF NANOPARTICLES MAGNETITE
I.V. Milto,1 I.V. Suhodolo,1 V.Yu. Usov 2
1 Siberian State Medical University, Tomsk and
2 Scientific research institute of cardiology of Siberian branch of the Russian academy of medical sciences, Tomsk;
e-mail: milto_bio@mail.ru
The article describes changes in the morphology and localization of the cells of mononuclear phagocyte system of liver and lung in rats at different times after single and repeated
intravenous administration of a suspension of nanoparticles of magnetite (NPM). Mechanisms for removal of nanoparticles of magnetite from the rat body with the participation of mononuclear
phagocytes of the liver (removal of the particles by stellate macrophages in the gastroenteric tract with bile) and of the lung (by migration of the alveolar macrophages in the gleam of the
bronchial tree) have been illustrated. It has been shown that intravenous application of nanomagnetite causes changes in the morphology of the internal organs of rats and the severity of these
changes increases with increasing total dose injected magnetite.
Key words: nanoparticles of magnetite, stellate (Kupfer's cell) and alveolar macrophages
