CURRENT INSIGHTS INTO CHROMATIN STRUCTURE ORGANIZATION
Andrey V. Ilatovskiy,1,2,* Dmitry V. Lebedev,1 Michael V. Filatov,1 Michael G. Petukhov 1,2
and Vladimir V. Isaev-Ivanov 1
1 Petersburg Nuclear Physics Institute, Gatchina, Russia, and
2 St. Petersburg State Polytechnic University, St. Petersburg, Russia;
* e-mail: andreyi@omrb.pnpi.spb.ru
This review summarizes current insights into organization of chromatin structure at different levels of DNA compaction. Analysis of available experimental data allowed
concluding that only nucleosomal level of structural organization was sufficiently investigated, whereas structure of a 30-nm chromatin fiber remains an open issue. The data on the
chromatin structure obtained at the level of the nucleus speak in favor of a biphasic fractal organization of chromatin.
Key words: DNA, chromatin, nucleosome, 30-nm fiber, fractal
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