EFFECT OF THE LIPOSOMAL FORM OF FLAVONOID—METAL COMPLEXES ON SKIN
REGENERATION AFTER CHEMICAL BURN
V.S. Shubina,1,2,* Yu.V. Shatalin 1,2
1 Institute of Theoretical and Experimental Biophysics RAS, Pushchino,
and 2 Pushchino State University;
* e-mail: shubinavictoria@rambler.ru
The effect of the liposomal form formed by taxifolin and metals of variable valency was investigated. It was
shown that the application of preparations based on the free flavonoid and its complexes with Fe(II/III) and
Cu(II) ions after chemical burns results in a more effective skin regeneration and the repair of hair follicles and
sebaceous glands. A tendency for a more effective wound healing after the applications of taxifolin—Cu(II) and
taxifolin—Fe(III) liposomal complexes versus control was observed. It was assumed that the mechanism of action
of these preparations is based on the oxidative polymerization and conjugation of the flavonoid, which results
in the utilization of toxic metabolites and lipid peroxidation products.
Key words: liposomes, complexes of taxifolin with metals of variable valency, chemical burn, skin regeneration
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