ANTINEOPLASTIC EFFECT OF HYDROGEL PROSPIDIN ON SEIDEL ASCITES HEPATOMA
USED AS A MODEL
P.M. Bychkovsky,1 T.L. Yurkshtovich,1 A.A. Kladiev,2,* M.Yu. Revtovich 3
1 Research Institute for Physical and Chemical Problems of BSU, Minsk, Belarus,
2 Biotechcompany TNK, Moscow, Russia,
and 3 N.N. Alexandrov National Cancer Center, Minsk, Belarus;
* e-mail: prospidin@yandex.ru
Antineoplastic effect of hydrogel dextran phosphate, hydrogel prospidin, and prospidin in an injectable preparation
has been assessed using Seidel ascites hepatoma as a model. Injectable and hydrogel prospidin in doses
from 250, 500 to 1000 mg/kg and hydrogel phosphate dextran in doses of 500 and 1000 mg/kg were administered
to rats intraperitoneally in a single dose in a volume of 1 or 2 ml per each 100 g of animal body weight. The
study has shown that irrespective of rats with Seidel ascites hepatoma and significantly increase in the dosage
of prospidin preparations and hydrogel dextran phosphate results in a longer average life expectancy of rats
Compared with its injectable variant, hydrogel prospidin appears to produce more than twice as high antineoplastic
effect, and is found to provide prolonged therapeutic effects, as well as cure of animals in more than 60 %
of cases.
Key words: Seidel ascites hepatoma, intraperitoneal chemotherapy, prospidin hydrogel
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