INTRACELLULAR GASEOUS MESSENGERS, NITRIC OXIDE, CARBON MONOXIDE
AND HYDROGEN SULFIDE PARTICIPATE IN APOPTOSIS REGULATION
N. V. Ryazantseva, E. G. Starikova, L. A. Tashireva, Ye. A. Stepovaya,
Yu. V. Starikov, I. A. Osihov, V. V. Novitsky
State Budget Educational Institution of High Professional Education «Siberian State Medical University» of Ministry
of Health and Social Development of the Russian Federation, Tomsk;
e-mail: to-elen@yandex.ru
In this paper, participation of gases, nitric oxide, carbon monoxide and hydrogen sulfide, in cell apoptosis
regulation has been analyzed according to the literature data and our own findings. Different mechanisms of nitric
oxide influence on apoptotic reaction including modulation of transcription factors activity and increase in
mitochondrion membrane permeabilisation are described. Brief description of the generation and signal transduction
pathways of carbon monoxide is presented. Pro- and antiapoptotic mechanisms of hydrogen sulfide influence
on cell fate are analyzed.
Key words: gaseous mediators, nitric oxide, carbon monoxide, hydrogen sulfide, apoptosis
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