CHARACTERISTICS AFFERENTS NEURONS OF SPINAL GANGLIONS SENSITIVE TO CAPSAICIN
Porseva V.V.
e-mail: gershi2001@yahoo.com
Morphological features of TRPV1+-, SP+-, CGRP+-, NF200+-neurons was studied in thoracic spinal ganglions in 3-month-old
rats under chemical deafferentation. Results have shown, that the above mentioned markers were found in from 6,5 up to 41,3 % of ganglionic neurons. The heterogeneity in control
group of nociceptive neurons was kept in capsaicin-treated animals. In both groups, TRPV1+-neurons were prevailed, populations of SP+-, CGRP+- and
NF200+-neurons formed smaller groups. Sensitivity to capsaicin was shown in largest neurons in each population, neurons in experimental group had smaller cross-sectional
area, particularly in group of TRPV1+-neurons.
Key words: neuron, spinal ganglion, immunohistochemistry, capsaicin, rat
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