REGULATION OF ENDOTHELIAL CELLS FUNCTIONS BY ULTRASONIC
SUPERNATANT OF STREPTOCOCCUS PYOGENES
E.A. Starikova, A.M. Lebedeva, L.A. Burova, I.S. Freidlin
Institute of Experimented Medicine of the North West Branch
of the Russian Academy of Medical Sciences, St. Petersburg;
e-mail: sopchelina@hotmail.com
Angiogenesis and vascular remodeling are vital components of inflammation. As an inflammation evolves,
vessels expand to supply nutrients and inflammatory mediators, sustaining the accumulation of activated immune
cells in the affected tissues. This study demonstrates that ultrasonic supernatant of Streptoccocus pyogenes has anti-
angiogenic properties: inhibit EA.hy 926 human endothelial cells metabolism, adhesion, migration, proliferation.
At the same time Streptococcal components inhibit signaling pathways that involve FAK and ERKl/2. These
effects are not associated with necrosis or apoptosis in cell culture. Taking together, our results suggest that impairing
angiogenic function of endothelial cells might contribute to the reduced tissue perfusion, hypoxia, and
subsequent regional tissue necrosis caused by Streptococci group A.
Key words: angiogenesis, inflammation, endothelial cells, adhesion, migration, proliferation, Streptococcus pyogenes
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