THE REACTION OF THE NEUROBLASTOMA CELLS IN THE CULTURE ON THE INFLUENCE OF TRETIONINE AND NEUROTOXINE
Yu. A. Magakian, Z. A. Karalyan, E. M. Karalova, L. O. Abroyan,
L. A. Akopyan, A. S. Awetisyan, Z. B. Semerdzhyan
Institute of Molecular Biology NAS RA, Yerevan;
e-mail: tigmag@sci.am
Effect of the tretionine (retinoid) and aluminum chloride (neurotoxin) on the growth and differentiation of
neuroblastoma cells in culture after their introduction into the medium separately and in combination was studied.
The introduction of these substances creates a new information field in the medium, which becomes apparent
by the reactions of neuroblastoma found on the populational and cellular levels of its organization. The presence
of tretionine stimulates proliferation and induces differentiation of the cells into astrocytes. Aluminum chloride
inhibits cell proliferation and enhances the process of their destruction in the monolayer. The variety of the reactions
of neuroblastoma cells to the presence of these substances in the medium indicates the existence and functioning
of a mechanism that selects from the information introduced only the portion which may contribute to
adaptation of neuroblastoma cells to the changed culture conditions.
Key words: aluminum chloride, cell culture, information theory, neuroblastoma, tretionine
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