MITOCHONDRIA INHERITANCE IN YEAST SACCHAROMYCES CEREVISIAE
A. Yu. Fizikova
St. Petersburg State University;
e-mail: fizikova@gmail.com
The review is devoted to the main mechanisms of mitochondria inheritance in yeast Saccharomyces cerevisiae. The genetic mechanisms of functionally active mitochondria
inheritance in eukaryotic cells is one of the most relevant in modern researches. A great number of genetic diseases are associated with mitochondria dysfunction. Plasticity of eukaryotic
cell metabolism according to the environmental changes is ensured by adequate mitochondria functioning by means of ATP synthesis coordination, reactive oxygen species accumulation,
apoptosis regulation and is an important factor of cell adaptation to stress. Mitochondria participation in important for cell vitality processes masters the presence of accurate mechanisms of
mitochondria functions regulation according to environment fluctuations. The mechanisms of mitochondria division and distribution are highly conserved. Baker yeast S. cerevisiae is an
ideal model object for mitochondria researches due to energetic metabolism lability, ability to switch over respiration to fermentation, and petite-positive phenotype. Correction of metabolism
according to the environmental changes is necessary for cell vitality. The influence of respiratory, carbon, amino acid and phosphate metabolism on mitochondria functions was shown.
As far as the mechanisms that stabilize functions of mitochondria and mtDNA are highly conserve, we can project yeast regularities on higher eukaryotes systems. This makes it possible to
approximate understanding the etiology and pathogenesis of a great number of human diseases.
Key words: yeast, mitochondria
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