THE MAMMALIAN AND THE HUMAN PRIMARY GERM CELLS. DIFFERENTIATION, IDENTIFICATION, MIGRATION
V. G. Kozhukhar
State Academy of Pediatrics, St. Petersburg;
e-mail: V.Kojukhar@yandex.ru
Last years many new facts on gene expression at the different stages of PGC development were obtained. The process of germline segregation in different species realizes in different
manner - as preformation or epigenesis. In the review the mechanisms of the mammalian and the human initial germ cell lineage specification are dicussed. Analisis of data on the identification
of PGC from the moment of initial detection in epiblast up to completion of migration to gonadal anlages was performed. Information on the PGC markers of the different stages of development,
the mechanisms of PGC migration towards genital ridges and the chemokines that direct migration is discussed.
Key words: primary germ cells, markers, migration, chemokines epiblast
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