CELLULAR FACTORS OF LOCAL PROTECTION UNDER COMMUNITY ACQUIRED PNEUMONIA
N. M. Kondrashova,1 N. G. Plekhova,2,* D. V. Zavorueva,1 L. M. Somova,2
B. I. Geltser,1 A. V. Kostyushko 1
1 IVladivostok State Medical University and 2 The Research Institute of Epidemiology and Microbiology,
Siberian Branch of RAMS, Vladivostok;
* e-mail: pl_nat@hotmail.com
The community acquired pneumonia (CAP) falls into the category of the most frequent human diseases and
is one of the leading causes of death from infectious diseases. The main components that characterize the inflammatory
process in the lungs at CAP include an increase in vascular permeability, and migration of neutrophils
and monocytes/macrophages to the foci of infectious agents inoculation, and the reactivity of these cells defines
the upshot of the disease. In the present work, a significant increase in the number of neutrophils and an increase
in the number of perishing cells depending on the gravity of current CAP were determined. Herewith, the
contents of necrotic neutrophils and macrophages in foci of inflammation dependent on the gravity of current
CAP, while the difference between the factors of apoptosis in these patients was not reliable. Apoptotic cell death
was mainly revealed in population of macrophages. Analysis of the phagocytic and enzymatic activities of
cells of the local defense of CAP patients showed that the state of unspecific resistance of their organisms largely
determined the severity of the disease and antibiotic treatment did not affect the normalization of neutrophils
and macrophages functions.
Key words: apoptosis, neutrophils, monocytes/macrophages, community acquired pneumonia
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